The role of macrophages in cancer development and therapy
Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …
development of tumors, modulation of neoangiogenesis, immune suppression, and …
Off-target effects in CRISPR/Cas9-mediated genome engineering
XH Zhang, LY Tee, XG Wang, QS Huang… - … Therapy-Nucleic Acids, 2015 - cell.com
CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the
functionality of genetic elements, creating genetically modified organisms as well as …
functionality of genetic elements, creating genetically modified organisms as well as …
Inference of CRISPR edits from Sanger trace data
Efficient and precise genome editing requires a fast, quantitative, and inexpensive assay to
assess genotype following editing. Here, we present ICE (Inference of CRISPR Edits), which …
assess genotype following editing. Here, we present ICE (Inference of CRISPR Edits), which …
Easy quantitative assessment of genome editing by sequence trace decomposition
EK Brinkman, T Chen, M Amendola… - Nucleic acids …, 2014 - academic.oup.com
The efficacy and the mutation spectrum of genome editing methods can vary substantially
depending on the targeted sequence. A simple, quick assay to accurately characterize and …
depending on the targeted sequence. A simple, quick assay to accurately characterize and …
[HTML][HTML] The CRISPR/Cas9 system for plant genome editing and beyond
Targeted genome editing using artificial nucleases has the potential to accelerate basic
research as well as plant breeding by providing the means to modify genomes rapidly in a …
research as well as plant breeding by providing the means to modify genomes rapidly in a …
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
Although RNA-guided genome editing via the CRISPR-Cas9 system is now widely used in
biomedical research, genome-wide target specificities of Cas9 nucleases remain …
biomedical research, genome-wide target specificities of Cas9 nucleases remain …
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
The Type II clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system
is an adaptive immune response in prokaryotes, protecting host cells against invading …
is an adaptive immune response in prokaryotes, protecting host cells against invading …
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
RNA-guided engineered nucleases (RGENs) derived from the prokaryotic adaptive immune
system known as CRISPR (clustered, regularly interspaced, short palindromic repeat)/Cas …
system known as CRISPR (clustered, regularly interspaced, short palindromic repeat)/Cas …
CRISPR/Cas9 genome editing in wheat
Genome editing has been a long-term challenge for molecular biology research, particularly
for plants possess complex genome. The recently discovered Clustered Regularly …
for plants possess complex genome. The recently discovered Clustered Regularly …
CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing
Major advances in genome editing have recently been made possible with the development
of the TALEN and CRISPR/Cas9 methods. The speed and ease of implementing these …
of the TALEN and CRISPR/Cas9 methods. The speed and ease of implementing these …