Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

Drug conjugates are chemotherapeutic or cytotoxic agents covalently linked to targeting
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …

The field of polymer therapeutics has evolved over the past decade and has resulted in the
development of polymer–drug conjugates with a wide variety of architectures and chemical …

In recent years, although many review articles have been presented about bioapplications of
magnetic nanoparticles by some research groups with different expertise such as chemistry …

The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

Polymer conjugation is an efficient approach to improve the delivery of drugs and biological
agents, both by protecting the body from the drug (by improving biodistribution and reducing …

Proteases play critical roles in virtually all biological processes, including proliferation, cell
death and survival, protein turnover, and migration. However, when dysregulated, these …

The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …

A growing number of polymer therapeutics have entered routine clinical use as nano-sized
medicines. Early products were developed as anticancer agents, but treatments for a range …

The increasing development of targeted cancer therapy provides extensive possibilities in
clinical trials, and numerous strategies have been explored. The prodrug is one of the most …