Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a lysosomal storage
disorder causing extensive demyelination in the central and peripheral nervous systems …

The brain remains one of the most challenging therapeutic targets due to the low and
selective permeability of the blood–brain barrier and complex architecture of the brain …

Stem cells capable of differentiating to multiple lineages may be valuable for therapy. We
report the isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express …

Background and Purpose—Intravascular delivery of neural stem cells (NSCs) after stroke
has been limited by the low efficiency of transendothelial migration. Vascular cell adhesion …

Globoid cell leukodystrophy (GLD) or Krabbe disease is a neurodegenerative disorder
caused by the deficiency of the lysosomal enzyme galactocerebrosidase (GALC). This …

Neural stem cells have been shown to participate in the repair of experimental CNS
disorders. To examine their potential in spinal cord repair, we used retroviral vectors to …

Krabbe disease is an autosomal recessive disorder resulting from defects in the lysosomal
enzyme galactocerebrosidase (GALC). GALC deficiency leads to severe neurological …

A large number of crippling neurological conditions result from the loss of certain cell
populations from the nervous system through disease or injury, and these cells are not …

This Review summarizes the progress in understanding the pathogenesis and treatment of
Krabbe disease from the description of five patients in by Knud Krabbe until 2016. To …

There are over 50 lysosomal hydrolase deficiencies, many of which cause
neurodegeneration, cognitive decline and death. In recent years, a number of broad …