By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

Efforts to fully understand pharmacological differences between G protein-coupled receptor
(GPCR) species homologues are generally not pursued in detail during the drug …

The sperm‐specific CatSper channel controls the intracellular Ca2+ concentration ([Ca2+] i)
and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by …

The aim of this study was to determine whether short-term, in vivo exposure to silver
nanoparticles (AgNPs) could be toxic to male reproduction. Low dose (1 mg/kg/dose) AgNPs …

The directional movement of cells can be regulated by ATP, certain other nucleotides (eg,
ADP, UTP), and adenosine. Such regulation occurs for cells that are “professional …

The signaling enzyme glycogen synthase kinase 3 (GSK3) exists as two isoforms—GSK3A
and GSK3B. Protein phosphorylation by GSK3 has important signaling roles in several cells …

Adenosine is an ubiquitous local modulator that regulates various physiological and
pathological functions by stimulating four membrane receptors, namely A1, A2A, A2B, and …

G protein-coupled receptors (GPCRs) transduce external chemical cues into intracellular
signals and are involved in a plethora of physiological processes, but knowledge regarding …

Adenosine in the normal kidney significantly elevates in response to cellular damage. The
renal A 3 adenosine receptor (A 3 AR) is up-regulated under stress, but the therapeutic …

Background Frequency and asymmetry of the flagellar waveform of sperm are controlled by
cAMP-mediated and Ca 2+-dependent signaling pathways, but additional mechanisms …