Preconception origins of asthma, allergies and lung function: the influence of previous generations on the respiratory health of our children

C Svanes, JW Holloway… - Journal of Internal …, 2023 - Wiley Online Library
Emerging research suggests that exposures occurring years before conception are
important determinants of the health of future offspring and subsequent generations …

The effects of microbiota on reproductive health: A review

N Wang, L Chen, K Yi, B Zhang, C Li… - Critical Reviews in Food …, 2024 - Taylor & Francis
Reproductive issues are becoming an increasing global problem. There is increasing
interest in the relationship between microbiota and reproductive health. Stable microbiota …

Parental high-fat high-sugar diet intake programming inflammatory and oxidative parameters of reproductive health in male offspring

MN Sertorio, H César, EA de Souza… - Frontiers in Cell and …, 2022 - frontiersin.org
Parental nutrition can impact the health of future generations, programming the offspring for
the development of diseases. The develo** germ cells of the offspring could be damaged …

Paternal high-fat diet altered SETD2 gene methylation in sperm of F0 and F1 mice

S Wei, S Luo, H Zhang, Y Li, J Zhao - Genes & Nutrition, 2023 - Springer
Paternal high-fat diet (HFD) can alter the epigenetics of sperm DNA, resulting in the
transmission of obesity-related traits to the offspring. Previous studies have mainly focused …

[HTML][HTML] Dapagliflozin ameliorates ovulation disorders via attenuating activated microglia-mediated hypothalamic inflammation in HFD-fed mice

X Chen, Z **ao, Q Liu, D Luo, Y Cai, M Fan - Neuroendocrinology, 2024 - karger.com
Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have shown
neuroprotective effects in obese mice. However, whether SGLT2i can ameliorate high-fat …

Behind the genetics: the role of epigenetics in infertility-related testicular dysfunction

A Crafa, R Cannarella, AE Calogero, S Gunes… - Life, 2024 - mdpi.com
In recent decades, we have witnessed a progressive decline in male fertility. This is partly
related to the increased prevalence of chronic diseases (eg, obesity and diabetes mellitus) …

Pre-reproductive stress in adolescent female rats alters maternal care and DNA methylation patterns across generations

H Zaidan, A Wnuk, IM Aderka, M Kajta… - Stress, 2023 - Taylor & Francis
Stress during development affects maternal behavior and offspring phenotypes. Stress in
adolescence is particularly consequential on brain development and maturation, and is …

Taurine and its transporter TAUT positively affect male reproduction and early embryo development

H Wu, X Zhang, J Yang, T Feng, Y Chen… - Human …, 2022 - academic.oup.com
STUDY QUESTION Are taurine and its transporter TAUT associated with spermiogenesis
and early embryo development? SUMMARY ANSWER Morphologically abnormal …

Dulaglutide reduces oxidative DNA damage and hypermethylation in the somatic cells of mice fed a high‐energy diet by restoring redox balance, inflammatory …

SM Attia, AA Alshamrani, SF Ahmad… - … of Biochemical and …, 2024 - Wiley Online Library
Obesity is an established risk factor for numerous malignancies, although it remains
uncertain whether the disease itself or weight‐loss drugs are responsible for a greater …

[HTML][HTML] Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidative Stress and Antioxidant Supplementation on DNA Methylation and …

E Hug, Y Renaud, R Guiton, M Ben Sassi, C Marcaillou… - Antioxidants, 2024 - mdpi.com
Reproductive success is dependent on gamete integrity, and oxidative stress alters male
nuclei, meaning that no DNA repair is possible due to chromatin compaction. The …