This article provides a contemporary review and a new perspective on the role of neprilysin
inhibition in heart failure (HF) in the context of recent clinical trials and addresses potential …

It has been said that COVID-19 is a generational challenge in many ways. But, at the same
time, it becomes a catalyst for collective action, innovation, and discovery. Realizing the full …

Brain CD11c+ cells share features with microglia and dendritic cells (DCs). Sterile
inflammation increases brain CD11c+ cells, but their phenotype, origin, and functions …

From January 2020, COVID-19 is spreading around the world producing serious respiratory
symptoms in infected patients that in some cases can be complicated by the severe acute …

Predicting which acromegaly patients could benefit from somatostatin receptor ligands
(SRL) is a must for personalized medicine. Although many biomarkers linked to SRL …

Background Chronic spontaneous urticaria (CSU) is a rare, heterogeneous, severely
debilitating, and often poorly controlled skin disease resulting in an itchy eruption which can …

Identifying immune correlates of protection and mechanisms of immunity accelerates and
streamlines the development of vaccines. RTS, S/AS01E, the most clinically advanced …

Background Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease
(AOSD) are manifestations of an autoinflammatory disorder with complex pathophysiology …

Objective Real‐world studies are needed to identify factors associated with response to
biologic therapies in patients with axial spondyloarthritis (SpA). The objective was to assess …

Regulatory agencies encourage computer modeling and simulation to reduce the time and
cost of clinical trials. Although still not classified in formal guidelines, system biology-based …