Principles of fluoride toxicity and the cellular response: a review

NR Johnston, SA Strobel - Archives of toxicology, 2020‏ - Springer
Fluoride is ubiquitously present throughout the world. It is released from minerals, magmatic
gas, and industrial processing, and travels in the atmosphere and water. Exposure to low …

Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches

AH Nagendra, B Bose, S Shenoy P - Molecular Biology Reports, 2021‏ - Springer
Fluoride is a natural element essential in minute quantities in human's to maintain dental
and skeletal health. However, the disease fluorosis manifests itself due to excessive fluoride …

[HTML][HTML] Fluoride enhances generation of reactive oxygen and nitrogen species, oxidizes hemoglobin, lowers antioxidant power and inhibits transmembrane electron …

N Maheshwari, N Qasim, R Anjum… - … and Environmental Safety, 2021‏ - Elsevier
Fluoride is a widespread environmental pollutant that at high levels exerts numerous
deleterious effects on human health. The toxic effects of fluoride are a matter of serious …

Impact of chronic sodium fluoride toxicity on antioxidant capacity, biochemical parameters, and histomorphology in cardiac, hepatic, and renal tissues of Wistar rats

P Sharma, PK Verma, S Sood, M Singh… - Biological Trace Element …, 2023‏ - Springer
The study was designed to determine the fluoride distribution after its oral exposure in
drinking water and its associated impact on biochemical, antioxidant markers and histology …

Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies

C Liang, Y Gao, Y He, Y Han, RK Manthari… - Environmental …, 2020‏ - Elsevier
It is very important to explore the potential harm and underlying mechanism of fluoride due
to the extensive distribution and the significant health risks of fluoride in environment. The …

Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor α …

SJ In, SH Kim, RE Go, KA Hwang… - Journal of Toxicology and …, 2015‏ - Taylor & Francis
Endocrine-disrupting chemicals (EDC) are defined as environmental compounds that
produce adverse health manifestations in mammals by disrupting the endocrine system …

Fluoride induces apoptosis in mammalian cells: in vitro and in vivo studies

DA Ribeiro, CM Cardoso, VQ Yujra… - Anticancer …, 2017‏ - ar.iiarjournals.org
Apoptosis is genetically programmed cell death, an irreversible process of cell senescence
with characteristic features different from other cellular mechanisms of death such as …

Effects of sodium fluoride on blood cellular and humoral immunity in mice

H Guo, P Kuang, Q Luo, H Cui, H Deng, H Liu… - …, 2017‏ - pmc.ncbi.nlm.nih.gov
Exposure to high fluorine can cause toxicity in human and animals. Currently, there are no
systematic studies on effects of high fluorine on blood cellular immunity and humoral …

[HTML][HTML] Fluoride stimulates the MAPK pathway to regulate endoplasmic reticulum stress and heat shock proteins to induce duodenal toxicity in chickens

Y Li, T Ma, X Lv, Z Qiu, S Li, J Qi, C Wei - Poultry Science, 2024‏ - Elsevier
Fluoride is one of the essential trace elements for body. However, excessive fluoride poses
a major threat to human and animal health. Fluorosis may cause pathological damage of the …

Evaluation of vascular and kidney injury biomarkers in Mexican children exposed to inorganic fluoride

MI Jiménez-Córdova, C González-Horta… - Environmental …, 2019‏ - Elsevier
Exposure to inorganic fluoride (F) has been implicated in cardiovascular and kidney
dysfunction mainly in adult populations. However, limited epidemiological information from …