Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Micellization of block copolymers
G Riess - Progress in polymer science, 2003 - Elsevier
This article deals with recent progress including the author's work in the field of block
copolymer self-assembly in solution and on solid surfaces. The synthesis methods for …
copolymer self-assembly in solution and on solid surfaces. The synthesis methods for …
Poly (ethylene oxide)–poly (propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs
DA Chiappetta, A Sosnik - European Journal of Pharmaceutics and …, 2007 - Elsevier
The low solubility in biological fluids displayed by about 50% of the drugs still remains the
main limitation in oral, parenteral, and transdermal administration. Among the existing …
main limitation in oral, parenteral, and transdermal administration. Among the existing …
Block copolymer micelles
JF Gohy - Block copolymers II, 2005 - Springer
This review summarizes recent advances to date in the area of block copolymer micelles
and also tries to highlight some new directions in that field. Generalities about the …
and also tries to highlight some new directions in that field. Generalities about the …
Aggregation of water-soluble block copolymers in aqueous solutions: recent trends
K Nakashima, P Bahadur - Advances in colloid and interface science, 2006 - Elsevier
This review summarizes recent literature and some of our own results on aggregation
behavior on water-soluble block copolymers belonging to three different classes viz …
behavior on water-soluble block copolymers belonging to three different classes viz …
Complex fluids of poly (oxyethylene) monoalkyl ether nonionic surfactants
R Dong, J Hao - Chemical reviews, 2010 - ACS Publications
Complex Fluids of Poly(oxyethylene) Monoalkyl Ether Nonionic Surfactants | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …
Tuneable enhancement of the salt and thermal stability of polymeric micelles by cyclized amphiphiles
S Honda, T Yamamoto, Y Tezuka - Nature communications, 2013 - nature.com
Cyclic molecules provide better stability for their aggregates. Typically in nature, the unique
cyclic cell membrane lipids allow thermophilic archaea to inhabit extreme conditions. By …
cyclic cell membrane lipids allow thermophilic archaea to inhabit extreme conditions. By …
Mixed micelle formation with hydrophobic and hydrophilic Pluronic block copolymers: implications for controlled and targeted drug delivery
SS Kulthe, NN Inamdar, YM Choudhari… - Colloids and Surfaces B …, 2011 - Elsevier
Pluronic block copolymers offer affluent phase behavioral characteristics and are
extensively investigated for drug delivery applications. Hydrophobic Pluronics produce …
extensively investigated for drug delivery applications. Hydrophobic Pluronics produce …
A small-angle neutron and X-ray contrast variation scattering study of the structure of block copolymer micelles: Corona shape and excluded volume interactions
Small-angle neutron and X-ray scattering data have been obtained for micelles of d-
polystyrene− polyisoprene (d-PS− PI) of relatively high molecular weight in n-decane …
polystyrene− polyisoprene (d-PS− PI) of relatively high molecular weight in n-decane …
Concentration, temperature, and salt-induced micellization of a triblock copolymer Pluronic L64 in aqueous media
JP Mata, PR Majhi, C Guo, HZ Liu, P Bahadur - Journal of colloid and …, 2005 - Elsevier
The effect of copolymer concentration, temperature, and sodium halides (NaI, NaBr, NaCl,
and NaF) on micellization and micellar properties of a poly (ethylene oxide)-block-poly …
and NaF) on micellization and micellar properties of a poly (ethylene oxide)-block-poly …