Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Micellization of block copolymers

G Riess - Progress in polymer science, 2003 - Elsevier
This article deals with recent progress including the author's work in the field of block
copolymer self-assembly in solution and on solid surfaces. The synthesis methods for …

Poly (ethylene oxide)–poly (propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs

DA Chiappetta, A Sosnik - European Journal of Pharmaceutics and …, 2007 - Elsevier
The low solubility in biological fluids displayed by about 50% of the drugs still remains the
main limitation in oral, parenteral, and transdermal administration. Among the existing …

Block copolymer micelles

JF Gohy - Block copolymers II, 2005 - Springer
This review summarizes recent advances to date in the area of block copolymer micelles
and also tries to highlight some new directions in that field. Generalities about the …

Aggregation of water-soluble block copolymers in aqueous solutions: recent trends

K Nakashima, P Bahadur - Advances in colloid and interface science, 2006 - Elsevier
This review summarizes recent literature and some of our own results on aggregation
behavior on water-soluble block copolymers belonging to three different classes viz …

Complex fluids of poly (oxyethylene) monoalkyl ether nonionic surfactants

R Dong, J Hao - Chemical reviews, 2010 - ACS Publications
Complex Fluids of Poly(oxyethylene) Monoalkyl Ether Nonionic Surfactants | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …

Tuneable enhancement of the salt and thermal stability of polymeric micelles by cyclized amphiphiles

S Honda, T Yamamoto, Y Tezuka - Nature communications, 2013 - nature.com
Cyclic molecules provide better stability for their aggregates. Typically in nature, the unique
cyclic cell membrane lipids allow thermophilic archaea to inhabit extreme conditions. By …

Mixed micelle formation with hydrophobic and hydrophilic Pluronic block copolymers: implications for controlled and targeted drug delivery

SS Kulthe, NN Inamdar, YM Choudhari… - Colloids and Surfaces B …, 2011 - Elsevier
Pluronic block copolymers offer affluent phase behavioral characteristics and are
extensively investigated for drug delivery applications. Hydrophobic Pluronics produce …

A small-angle neutron and X-ray contrast variation scattering study of the structure of block copolymer micelles: Corona shape and excluded volume interactions

JS Pedersen, C Svaneborg, K Almdal… - …, 2003 - ACS Publications
Small-angle neutron and X-ray scattering data have been obtained for micelles of d-
polystyrene− polyisoprene (d-PS− PI) of relatively high molecular weight in n-decane …

Concentration, temperature, and salt-induced micellization of a triblock copolymer Pluronic L64 in aqueous media

JP Mata, PR Majhi, C Guo, HZ Liu, P Bahadur - Journal of colloid and …, 2005 - Elsevier
The effect of copolymer concentration, temperature, and sodium halides (NaI, NaBr, NaCl,
and NaF) on micellization and micellar properties of a poly (ethylene oxide)-block-poly …