The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

The association between serum uric acid levels and high blood pressure in humans is well
established. For example, a cross-sectional study determined that each 1mg/dL increase in …

Endothelial cells line all blood vessels and are critical regulators of vascular tone. In
hypertension, disruption of endothelial function alters the release of endothelial-derived …

Over the past 66 years, our knowledge of the role of the endothelium in the regulation of
cardiovascular function and dysfunction has advanced from the assumption that it is a single …

Background and Purpose The TRPV4 ion channels are Ca2+ permeable, non‐selective
cation channels that mediate large, but highly localized, Ca2+ signals in the endothelium …

Arteries and veins are lined by nonproliferating endothelial cells that play a critical role in
regulating blood flow. Endothelial cells also regulate tissue perfusion, metabolite exchange …

Background Obesity is a major risk factor for diabetes and cardiovascular diseases such as
hypertension, heart failure, and stroke. Impaired endothelial function occurs in the earliest …

Pressure myography, one of the most commonly used techniques in vascular research,
measures the diameter of isolated, pressurized arteries to assess the functional activity of …

Protein localization in endothelial cells is tightly regulated to create distinct signaling
domains within their tight spatial restrictions including luminal membranes, abluminal …