The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

Objective The aim of this study was to analyse the clinical characteristics of acute
pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the …

This paper reviews the current status of our understanding of the epidemiology, diagnosis,
and management of the continuum of pancreatic diseases from acute and recurrent acute …

Bile acids are a class of cholesterol derivatives that have been known for a long time for their
critical roles in facilitating the digestion and absorption of lipid from the daily diet. The …

Background & Aims High mobility group box 1 (HMGB1) is an abundant protein that
regulates chromosome architecture and also functions as a damage-associated molecular …

Alcohol-related acute pancreatitis can be mediated by a combination of alcohol and fatty
acids (fatty acid ethyl esters) and is initiated by a sustained elevation of the Ca2+ …

New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …