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The substrate repertoire of γ-secretase/presenilin
G Güner, SF Lichtenthaler - Seminars in cell & developmental biology, 2020 - Elsevier
The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments
Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …
translational modification that controls levels and function of hundreds of membrane …
ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion
The severe‐acute‐respiratory‐syndrome‐coronavirus‐2 (SARS‐CoV‐2) is the causative
agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only …
agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only …
Trafficking and proteolytic processing of APP
C Haass, C Kaether… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …
Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue
BJ Berube, J Bubeck Wardenburg - Toxins, 2013 - mdpi.com
Staphylococcus aureus secretes a number of host-injurious toxins, among the most
prominent of which is the small β-barrel pore-forming toxin α-hemolysin. Initially named …
prominent of which is the small β-barrel pore-forming toxin α-hemolysin. Initially named …
Metalloproteinases and their natural inhibitors in inflammation and immunity
Over the past 50 years, steady growth in the field of metalloproteinase biology has shown
that the degradation of extracellular matrix components represents only a fraction of the …
that the degradation of extracellular matrix components represents only a fraction of the …
[HTML][HTML] The canonical Notch signaling pathway: unfolding the activation mechanism
Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Animal models of Alzheimer disease
Significant insights into the function of genes associated with Alzheimer disease and related
dementias have occurred through studying genetically modified animals. Although none of …
dementias have occurred through studying genetically modified animals. Although none of …
The secretases: enzymes with therapeutic potential in Alzheimer disease
The amyloid hypothesis has yielded a series of well-validated candidate drug targets with
potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in …
potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in …
ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons
PH Kuhn, H Wang, B Dislich, A Colombo… - The EMBO …, 2010 - embopress.org
The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity
called α‐secretase. This is considered an important mechanism preventing the generation of …
called α‐secretase. This is considered an important mechanism preventing the generation of …