Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

The versatile role of mast cells in allergy, in innate immune responses and in the regulation
of tissue homeostasis is well recognized. However, it is often not made clear that most mast …

The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

Allergic diseases are complex genetic diseases resulting from the effect of multiple genetic
and interacting environmental factors on their pathophysiology. Recent years have seen …

Asthma and eczema (atopic dermatitis) are the most common chronic diseases of childhood.
These diseases are characterized by the production of high levels of immunoglobulin E in …

Objective: Patient samples used for map** complex human disease genes are unlikely to
be representative of the phenotype spectrum of the respective population as a whole. On the …

Immunological activation of mast cells is an important trigger in the cascade of inflammatory
events leading to the manifestation of allergic diseases. Pharmacological studies using the …

The normal gastrointestinal (GI) mucosa is equipped with mast cells that account for 2–3% of
lamina propria cells under normal conditions. Mast cells are generally associated with …

Abstract Prostaglandin D 2 (PGD 2) released by degranulating mast cells is believed to play
a key role in orchestrating mechanisms of inflammation in allergies and asthma. The …

Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …