Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Membrane microdomains with distinct lipid compositions, called lipid rafts, represent a
potential mechanism for compartmentalizing cellular functions within the plane of biological …

Lipid rafts are sphingolipid‐and cholesterol‐rich domains of the plasma membrane which
contain a variety of signalling and transport proteins. Different subtypes of lipid rafts can be …

Like all other monomeric or multimeric transmembrane proteins, receptors for
neurotransmitters are surrounded by a shell of lipids which form an interfacial boundary …

Prions are the causative agent of the transmissible spongiform encephalopathies, such as
Creutzfeldt-Jakob disease in humans. In these prion diseases the normal cellular form of the …

Our laboratory was interested in characterizing the molecular composition of non-caveolar
lipid rafts. Thus, we generated monoclonal antibodies to lipid raft proteins of human …

Polarized distribution of plasma membrane transporters and receptors in epithelia is
essential for vectorial functions of epithelia. This polarity is maintained by sorting of …

Amyloid diseases display the presence, in targeted tissues and organs, of fibrillar deposits of
specific peptides or proteins. Increasing efforts are presently spent in investigating the …

Alzheimer, Parkinson and other neurodegenerative diseases involve a series of brain
proteins, referred to as 'amyloidogenic proteins', with exceptional conformational plasticity …

Lipids were long believed to have a structural role in biomembranes and a role in energy
storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last …