Highlights•Sixteen leading groups review evidence for the therapeutic effects of
agmatine.•Agmatine modulatory action at multiple molecular targets is highlighted.• …

Suicide is a major public health concern and a leading cause of death in most societies.
Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It …

Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …

Depression is a global health concern affecting nearly 280 million individuals. It not only
imposes a significant burden on economies and healthcare systems but also manifests …

Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling
pathways. Several studies have focused on elucidating the mechanisms underlying the …

Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first
discovered in 1910, but its physiological significance was disregarded for a century. The …

Major depressive disorder (MDD) is a disabling and highly prevalent mood disorder as well
as a common cause of suicide. Chronic stress, inflammation, and intestinal dysbiosis have …

The risk of psychiatric and neurological disorders is significantly higher in patients with
diabetes mellitus. Diabetic patients are more susceptible to depression, anxiety and memory …

Major depressive disorder is the most common psychiatric disorder with lifetime prevalence
of up to 20% worldwide. It is responsible for more years lost to disability than any other …

Premenstrual dysphoric disorder (PMDD) is characterized by various physical and affective
symptoms, including anxiety, irritability, anhedonia, social withdrawal, and depression. The …