Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research
SG Potkin, JM Kane, CU Correll, JP Lindenmayer… - NPJ …, 2020 - nature.com
Abstract Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms
despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …
despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
Neuroimaging biomarkers in schizophrenia
NV Kraguljac, WM McDonald… - American Journal of …, 2021 - Am Psychiatric Assoc
Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …
A guideline and checklist for initiating and managing clozapine treatment in patients with treatment-resistant schizophrenia
Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …
Treatment resistant schizophrenia: Clinical, biological, and therapeutic perspectives
Abstract Treatment resistant schizophrenia (TRS) refers to the significant proportion of
schizophrenia patients who continue to have symptoms and poor outcomes despite …
schizophrenia patients who continue to have symptoms and poor outcomes despite …
Heterogeneity and homogeneity of regional brain structure in schizophrenia: a meta-analysis
SP Brugger, OD Howes - JAMA psychiatry, 2017 - jamanetwork.com
Importance Schizophrenia is associated with alterations in mean regional brain volumes.
However, it is not known whether the clinical heterogeneity seen in the disorder is reflected …
However, it is not known whether the clinical heterogeneity seen in the disorder is reflected …
Association of age, antipsychotic medication, and symptom severity in schizophrenia with proton magnetic resonance spectroscopy brain glutamate level: a mega …
Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
Schizophrenia: from neurochemistry to circuits, symptoms and treatments
Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …