Mice that make VL binding proteins
L MacDonald, S Stevens, C Gurer, KA Hosiawa… - US Patent …, 2016 - Google Patents
Genetically modified mice and methods for making an using them are provided, wherein the
mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene …
mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human—non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Humanized light chain mice
L MacDonald, C Gurer, KA Hosiawa, S Stevens… - US Patent …, 2017 - Google Patents
Non-human animals, tissues, cells, and genetic material are provided that comprise a
modification of an endogenous non-human heavy chain immunoglobulin sequence and that …
modification of an endogenous non-human heavy chain immunoglobulin sequence and that …
Mice that make VL binding proteins
L MacDonald, S Stevens, C Gurer, KA Meagher… - US Patent …, 2017 - Google Patents
2005/0060763 A1 3/2005 Bruggeman et al. WO WO-2008/O54606 A2 5, 2008
2005.0246782 A1 11, 2005 Etches et al. WO 2008/O76379 A2 6/2008 2006/0015957 A1 …
2005.0246782 A1 11, 2005 Etches et al. WO 2008/O76379 A2 6/2008 2006/0015957 A1 …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …