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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …
host cell factors have been implicated in its formation. In particular, recent results have …
[HTML][HTML] Transcription factors in cancer: when alternative splicing determines opposite cell fates
Alternative splicing (AS) is a finely regulated mechanism for transcriptome and proteome
diversification in eukaryotic cells. Correct balance between AS isoforms takes part in …
diversification in eukaryotic cells. Correct balance between AS isoforms takes part in …
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
We studied human immunodeficiency virus, type 1 (HIV-1) integrase (IN) complexes derived
from nuclei of human cells stably expressing the viral protein from a synthetic gene. We …
from nuclei of human cells stably expressing the viral protein from a synthetic gene. We …
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
The asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a) acts as a repressive
mark that antagonizes trimethylation of H3 lysine 4. Here we report that H3R2 is also …
mark that antagonizes trimethylation of H3 lysine 4. Here we report that H3R2 is also …
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
We have reported that human immunodeficiency virus type 1 (HIV-1) integrase (IN) forms a
specific nuclear complex with human lens epithelium-derived growth factor/transcription co …
specific nuclear complex with human lens epithelium-derived growth factor/transcription co …
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 …
Human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75)
protein was recently identified as a binding partner for HIV-1 integrase (IN) in human cells. In …
protein was recently identified as a binding partner for HIV-1 integrase (IN) in human cells. In …
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration …
Human immunodeficiency virus type 1 (HIV-1), feline immunodeficiency virus (FIV), and
Moloney murine leukemia virus (MoMLV) integrases were stably expressed to determine …
Moloney murine leukemia virus (MoMLV) integrases were stably expressed to determine …
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding
K Busschots, J Vercammen, S Emiliani… - Journal of Biological …, 2005 - jbc.org
We have previously shown that the p75 isoform of the transcriptional co-activator lens
epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency …
epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency …
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus
After identifying the interaction between the transcriptional coactivator lens epithelium-
derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) …
derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) …
The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding
Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …