Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering

REB Fitzsimmons, MS Mazurek, A Soos… - Stem cells …, 2018 - Wiley Online Library
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

[HTML][HTML] A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan

S Brandhorst, IY Choi, M Wei, CW Cheng, S Sedrakyan… - Cell metabolism, 2015 - cell.com
Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly
understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in develo** cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

[HTML][HTML] Biologics for tendon repair

D Docheva, SA Müller, M Majewski… - Advanced drug delivery …, 2015 - Elsevier
Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly
because these injuries often respond poorly to treatment and require prolonged …

[HTML][HTML] Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRα-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats

M Li, Y Yu, K Xue, J Li, G Son, J Wang, W Qian… - Redox biology, 2023 - Elsevier
Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic
oxidative stress is an important factor contributes to the postmenopausal osteoporosis …

Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends

TH Qazi, DJ Mooney, M Pumberger, S Geissler… - Biomaterials, 2015 - Elsevier
Skeletal muscles have a robust capacity to regenerate, but under compromised conditions,
such as severe trauma, the loss of muscle functionality is inevitable. Research carried out in …

How smart do biomaterials need to be? A translational science and clinical point of view

BM Holzapfel, JC Reichert, JT Schantz… - Advanced drug delivery …, 2013 - Elsevier
Over the last 4 decades innovations in biomaterials and medical technology have had a
sustainable impact on the development of biopolymers, titanium/stainless steel and …

Tendon injuries: Basic science and new repair proposals

F Wu, M Nerlich, D Docheva - EFORT open reviews, 2017 - eor.bioscientifica.com
Tendons connect muscles to bones, ensuring joint movement. With advanced age, tendons
become more prone to degeneration followed by injuries. Tendon repair often requires …

Mitochondrial dynamics: fission and fusion in fate determination of mesenchymal stem cells

L Ren, X Chen, X Chen, J Li, B Cheng… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …