[HTML][HTML] Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds
The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
has resulted in a long pandemic, with numerous cases and victims worldwide and enormous …
has resulted in a long pandemic, with numerous cases and victims worldwide and enormous …
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
Potent bioactive compounds from seaweed waste to combat cancer through bioinformatics investigation
The seaweed industries generate considerable amounts of waste that must be appropriately
managed. This biomass from marine waste is a rich source of high-value bioactive …
managed. This biomass from marine waste is a rich source of high-value bioactive …
Structure-based virtual screening, molecular docking, molecular dynamics simulation, and metabolic reactivity studies of quinazoline derivatives for their anti-EGFR …
Background: Epidermal growth factor receptor (EGFR/HER-1) and its role in tumor
development and progression through the mechanism of tumor angiogenesis is prevalent in …
development and progression through the mechanism of tumor angiogenesis is prevalent in …
Echinacoside upregulates Sirt1 to suppress endoplasmic reticulum stress and inhibit extracellular matrix degradation in vitro and ameliorates osteoarthritis in vivo
Z Lin, C Teng, L Ni, Z Zhang, X Lu, J Lou… - Oxidative medicine …, 2021 - Wiley Online Library
Background. Osteoarthritis (OA) is a progressive illness that destroys cartilage. Oxidative
stress is a major contributor of OA, while endoplasmic reticulum (ER) stress is the key …
stress is a major contributor of OA, while endoplasmic reticulum (ER) stress is the key …
[HTML][HTML] **hua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and …
J Zeng, X Li, R Cai, C Li, S Chen - Journal of Food and Drug …, 2023 - ncbi.nlm.nih.gov
The study combined UHPLC-Q-Orbitrap-MS analysis with authentic standards, to create a
novel strategy for isomers recognition and putative identification. Through the strategy, anti …
novel strategy for isomers recognition and putative identification. Through the strategy, anti …
Exploration of potent antiviral phytomedicines from Lauraceae family plants against SARS-CoV-2 RNA-dependent RNA polymerase
AA Rabaan, MA Halwani, M Aljeldah… - Journal of …, 2023 - Taylor & Francis
RNA-dependent RNA polymerase, also known as RdRp, is a possible therapeutic target that
could be used to suppress the proliferation of RNA viruses such as SARS-CoV-2. This …
could be used to suppress the proliferation of RNA viruses such as SARS-CoV-2. This …
Discovery of Small Molecules from Echinacea angustifolia Targeting RNA-Dependent RNA Polymerase of Japanese Encephalitis Virus
The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes viral
encephalitis leading to neural damage, is a major threat in most Asian countries. The RNA …
encephalitis leading to neural damage, is a major threat in most Asian countries. The RNA …
Computational and in vitro experimental investigations reveal anti-viral activity of licorice and glycyrrhizin against severe acute respiratory syndrome coronavirus 2
Without effective antivirals, the COVID-19 pandemic will likely continue to substantially affect
public health. Medicinal plants and phytochemicals are attractive therapeutic options …
public health. Medicinal plants and phytochemicals are attractive therapeutic options …
Virtual combinatorial library screening of quinadoline B derivatives against SARS-CoV-2 RNA-dependent RNA polymerase
The unprecedented global health threat of SARS-CoV-2 has sparked a continued interest in
discovering novel anti-COVID-19 agents. To this end, we present here a computer-based …
discovering novel anti-COVID-19 agents. To this end, we present here a computer-based …