The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

The neocortex is the seat of higher cognitive functions and, in evolutionary terms, is the
youngest part of the mammalian brain. Since its origin, the neocortex has expanded in …

The classic view of cortical development, embodied in the radial unit hypothesis, highlights
the ventricular radial glia (vRG) scaffold as a key architectonic feature of the develo** …

Cortical neurogenesis follows a simple lineage: apical radial glia cells (RGCs) generate
basal progenitors, and these produce neurons. How this occurs in species with expanded …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Cortical folding is a hallmark of many, but not all, mammalian brains. The degree of folding
increases with brain size across mammals, but at different scales between orders and …

One of the most prominent features of the human brain is the fabulous size of the cerebral
cortex and its intricate folding. Cortical folding takes place during embryonic development …

Since descriptions of neural precursor cells (NPCs) were published in the late 19th century,
neuroanatomists have used a variety of terms to describe these cells, each term reflecting …