The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities
Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number
of PCa patients continues to rise despite the availability of effective treatments in recent …
of PCa patients continues to rise despite the availability of effective treatments in recent …
Beyond cisplatin: New frontiers in metallodrugs for hard-to-treat triple negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive and hard-to-treat form of breast
cancer. TNBC has a higher propensity for earlier relapse and an increased risk of metastasis …
cancer. TNBC has a higher propensity for earlier relapse and an increased risk of metastasis …
[HTML][HTML] Next-generation immunotherapy: advancing clinical applications in cancer treatment
P Garg, S Pareek, P Kulkarni, D Horne… - Journal of Clinical …, 2024 - mdpi.com
Next-generation immunotherapies have revolutionized cancer treatment, offering hope for
patients with hard-to-treat tumors. This review focuses on the clinical applications and …
patients with hard-to-treat tumors. This review focuses on the clinical applications and …
Tumor‐Tailored Ionizable Lipid Nanoparticles Facilitate IL‐12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy
The advancement of message RNA (mRNA)‐based immunotherapies for cancer is highly
dependent on the effective delivery of RNA (Ribonucleic) payloads using ionizable lipid …
dependent on the effective delivery of RNA (Ribonucleic) payloads using ionizable lipid …
Mirabegron displays anticancer effects by globally browning adipose tissues
X Sun, W Sui, Z Mu, S **e, J Deng, S Li, T Seki… - Nature …, 2023 - nature.com
Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on
augmented glycolytic metabolism to support their growth, invasion, and metastasis …
augmented glycolytic metabolism to support their growth, invasion, and metastasis …
Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development …
An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-
grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several …
grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several …
Molecular Dynamics Simulation and Pharmacoinformatic Integrated Analysis of Bioactive Phytochemicals from Azadirachta indica (Neem) to Treat Diabetes Mellitus
Diabetes mellitus is a chronic hormonal and metabolic disorder in which our body cannot
generate necessary insulin or does not act in response to it, accordingly, ensuing in …
generate necessary insulin or does not act in response to it, accordingly, ensuing in …
[HTML][HTML] Advancing cholangiocarcinoma care: Insights and innovations in T cell therapy
Simple Summary This review article explores the potential of CAR T cell therapy in treating
cholangiocarcinoma (CCA), a highly aggressive and difficult-to-treat cancer of the bile ducts …
cholangiocarcinoma (CCA), a highly aggressive and difficult-to-treat cancer of the bile ducts …
[HTML][HTML] Predictive Biomarkers and Resistance Mechanisms of Checkpoint Inhibitors in Malignant Solid Tumors
LA Pavelescu, RM Enache, OA Roşu, M Profir… - International Journal of …, 2024 - mdpi.com
Predictive biomarkers for immune checkpoint inhibitors (ICIs) in solid tumors such as
melanoma, hepatocellular carcinoma (HCC), colorectal cancer (CRC), non-small cell lung …
melanoma, hepatocellular carcinoma (HCC), colorectal cancer (CRC), non-small cell lung …
[HTML][HTML] Peptide-based inhibitors targeting the PD-1/PD-L1 axis: potential immunotherapeutics for cancer
Abstract The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints
and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for …
and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for …