Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress
conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) …

Viruses must co-opt the cellular translation machinery to produce progeny virions.
Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation …

The ability to control translation of endogenous or exogenous RNAs in eukaryotic cells
would facilitate a variety of biotechnological applications. Current strategies are limited by …

A nucleotide repeat expansion (NRE) within the chromosome 9 open reading frame 72
(C9orf72) gene was the first of this type of mutation to be linked to multiple neurological …

Internal ribosome entry sites (IRESs) can be found in the mRNA of many viruses as well as
in cellular genes involved in the stress response, cell cycle, and apoptosis. IRES-mediated …

The scanning model for eukaryotic mRNA translation initiation states that the small
ribosomal subunit, along with initiation factors, binds at the cap structure at the 5′ end of …

To ensure efficient propagation, viruses need to rapidly produce viral proteins after cell
entrance. Since viral genomes do not encode any components of the protein biosynthesis …

Internal ribosome entry sites (IRESs) mediate cap-independent translation of viral mRNAs.
Using electron cryo-microscopy of a single specimen, we present five ribosome structures …

Although viruses require cellular functions to replicate, their absolute dependence upon the
host translation machinery to produce polypeptides indispensable for their reproduction is …

Viral protein synthesis is completely dependent upon the host cell's translational machinery.
Canonical translation of host mRNAs depends on structural elements such as the 5′ cap …