Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

E Parra, J Pérez-Gil - Chemistry and physics of lipids, 2015 - Elsevier
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

BRICHOS domain associated with lung fibrosis, dementia and cancer–a chaperone that prevents amyloid fibril formation?

H Willander, E Hermansson, J Johansson… - The FEBS …, 2011 - Wiley Online Library
The BRICHOS domain was initially defined from sequence alignments of the Bri protein
associated with familial dementia, chondromodulin associated with chondrosarcoma and …

Identification and characterization of Cercospora beticola necrosis‐inducing effector CbNip1

MK Ebert, LI Rangel, RE Spanner… - Molecular Plant …, 2021 - Wiley Online Library
Cercospora beticola is a hemibiotrophic fungus that causes cercospora leaf spot disease of
sugar beet (Beta vulgaris). After an initial symptomless biotrophic phase of colonization …

Hydrophobic pulmonary surfactant proteins SP-B and SP-C induce pore formation in planar lipid membranes: evidence for proteolipid pores

E Parra, A Alcaraz, A Cruz, VM Aguilella, J Pérez-Gil - Biophysical journal, 2013 - cell.com
Pulmonary surfactant is a complex mixture of lipids and specific surfactant proteins,
including the hydrophobic proteins SP-B and SP-C, in charge of stabilizing the respiratory …

Effect of lung surfactant protein SP-C and SP-C-promoted membrane fragmentation on cholesterol dynamics

N Roldan, TKM Nyholm, JP Slotte, J Pérez-Gil… - Biophysical journal, 2016 - cell.com
To allow breathing and prevent alveolar collapse, lung surfactant (LS) develops a complex
membranous system at the respiratory surface. LS is defined by a specific protein and lipid …

Oligomerization domain of the multidrug resistance–associated transporter ABCG2 and its dominant inhibitory activity

J Xu, H Peng, Q Chen, Y Liu, Z Dong, JT Zhang - Cancer research, 2007 - AACR
Overexpression of human ATP-binding cassette transporter ABCG2 in cancer cells causes
multidrug resistance by effluxing anticancer drugs. ABCG2 is considered as a half …

[HTML][HTML] Pulmonary surfactant-derived antiviral actions at the respiratory surface

M Isasi-Campillo, P Losada-Oliva, J Pérez-Gil… - Current Opinion in …, 2023 - Elsevier
Lung surfactant (LS) is a membrane-based lipid-protein complex that lines the alveoli,
reducing the surface tension at the air-liquid interface and thus minimizing the work of …

Structural role of glycine in amyloid fibrils formed from transmembrane α-helices

W Liu, E Crocker, W Zhang, JI Elliott, B Luy, H Li… - Biochemistry, 2005 - ACS Publications
Amyloid fibrils associated with diseases such as Alzheimer's are often derived from the
transmembrane helices of membrane proteins. It is known that the fibrils have a cross-β …

Hydrophobic surfactant proteins and their analogues

FJ Walther, AJ Waring, MA Sherman, JA Zasadzinski… - Neonatology, 2007 - karger.com
Lung surfactant is a complex mixture of phospholipids and four surfactant-associated
proteins (SP-A, SP-B, SP-C and SP-D). Its major function in the lung alveolus is to reduce …

Divide & conquer: surfactant protein SP-C and cholesterol modulate phase segregation in lung surfactant

N Roldan, J Pérez-Gil, MR Morrow, B García-Álvarez - Biophysical journal, 2017 - cell.com
Lung surfactant (LS) is an essential system supporting the respiratory function. Cholesterol
can be deleterious for LS function, a condition that is reversed by the presence of the …