Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Autophagy is an evolutionarily conserved process for the degradation of redundant or
damaged cellular material by means of a lysosome-dependent mechanism, contributing to …

Neurodegenerative diseases (NDs) are currently incurable diseases that cause progressive
degeneration of nerve cells. Many of the disease-causing proteins of NDs are “undruggable” …

Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …

Glucocorticoid (GC) is one of the most prescribed medicines to treat various inflammatory
and autoimmune diseases. However, high doses and long-term use of GCs lead to multiple …

The incidence of diabetes has been increasing in recent decades which is affecting the
population of both, developed and develo** countries. Diabetes is associated with micro …

Autophagosome-tethering compounds (ATTECs) are an emerging new technology in
targeted protein degradation. However, effective tools and successful examples for …

Lung transplantation is the most effective therapy for patients with end-stage lung disease.
However, concern of donor lung damage and ischemia-reperfusion induced lung injury …

Immunotherapy has attracted widespread attention in cancer treatment and has achieved
considerable success in the clinical treatment of some tumors, but it has a low response rate …