Voltage-gated sodium and calcium channels are evolutionarily related transmembrane
signaling proteins that initiate action potentials, neurotransmission, excitation-contraction …

Voltage-gated sodium, calcium, and potassium channels generate electrical signals
required for action potential generation and conduction and are the molecular targets for a …

The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …

Sodium ion (Na+) channels, which initiate the action potential in electrically excitable cells,
are the molecular targets of local anesthetic drugs. Site-directed mutations in …

Ca2+ antagonist drugs are widely used in therapy of cardiovascular disorders,. Three
chemical classes of drugs bind to three separate, but allosterically interacting, receptor sites …

Voltage-gated sodium channels initiate action potentials in nerve, muscle, and other
electrically excitable cells. Voltage-gated calcium channels are activated by depolarization …

When a vertebrate skeletal muscle fibre is activated by a nerve impulse, an action potential
spreads from the endplate region along the whole fibre. It enters the transverse tubular …

▪ Abstract The crucial role of L-type Ca2+ channels in the initiation of cardiac and smooth
muscle contraction has made them major therapeutic targets for the treatment of …

Publisher Summary This chapter provides an overview of dendritic cells (DCs). Dendritic
cells were first identified in the epidermis and were termed “Langerhans cells.” DCs are now …

There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR)
membrane in cardiac myocytes. The relationship between channel structure, associated …