Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …

Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for
understanding the pathophysiology of cardiovascular disease, diabetes, cancer and …

Fatty liver disease is one of the most prevalent forms of chronic liver disease that
encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease …

Genetic analyses previously implicated the matrix-localized protease ClpP in signaling the
stress of protein misfolding in the mitochondrial matrix to activate nuclear-encoded …

Alcohol consumption is one of the leading causes of the global burden of disease and
results in high healthcare and economic costs. Heavy alcohol misuse leads to alcohol …

Acute and chronic ethanol treatment has been shown to increase the production of reactive
oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many …

Mitochondria are key organelles involved in energy production as well as numerous
metabolic processes. There is a growing interest in the role of mitochondrial dysfunction in …

Alcohol dependence is correlated with a wide spectrum of medical, psychological,
behavioral, and social problems. Acute alcohol abuse causes damage to and functional …

Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes
has emerged as a serious public health problem. Steatosis, accumulation of triglyceride in …

Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …