A century after the identification of a coenzymatic activity for NAD+, NAD+ metabolism has
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …

Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis
can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which …

Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche.
Overall, the signaling that regulates stem cell dormancy in the HSC niche remains …

Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the
NAD biosynthetic pathway. Three human NMNAT isoforms have recently been identified, but …

The numerous biological roles of NAD+ are organized and coordinated via its
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …

The pyridine nucleotides, NAD+ and NADH, are coenzymes that provide oxidoreductive
power for the generation of ATP by mitochondria. In skeletal muscle, exercise perturbs the …

Abstract In the C57BL/Wld S mouse, a dominant mutation dramatically delays Wallerian
degeneration in injury and disease, possibly by influencing multi-ubiquitination. Studies on …

This review describes the enzymes involved in human pyridine nucleotide metabolism
starting with a detailed consideration of their major kinetic, molecular and structural …

The enzyme nicotinamide mononucleotide adenylyltransferase is an ubiquitous enzyme
catalyzing an essential step in NAD (NADP) biosynthetic pathway. In human cells, the …

1. ABSTRACT NAD biosynthesis has become of considerable interest owing to the important
signaling functions of the pyridine nucleotides which have been recognized over the past …