Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Abstract The Allele Frequency Net Database (AFND, www. allelefrequencies. net) provides
the scientific community with a freely available repository for the storage of frequency data …
the scientific community with a freely available repository for the storage of frequency data …
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
It was recently shown that the major genetic risk factor associated with becoming severely ill
with COVID-19 when infected by severe acute respiratory syndrome coronavirus 2 (SARS …
with COVID-19 when infected by severe acute respiratory syndrome coronavirus 2 (SARS …
Tracing the peopling of the world through genomics
Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …
peoples have facilitated a number of breakthroughs in our understanding of human …
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present …
indicate that many hominin lineage branches arose, but only one survived to the present …
[HTML][HTML] Analysis of human sequence data reveals two pulses of archaic Denisovan admixture
Anatomically modern humans interbred with Neanderthals and with a related archaic
population known as Denisovans. Genomes of several Neanderthals and one Denisovan …
population known as Denisovans. Genomes of several Neanderthals and one Denisovan …
The complete genome sequence of a Neanderthal from the Altai Mountains
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We
show that her parents were related at the level of half-siblings and that mating among close …
show that her parents were related at the level of half-siblings and that mating among close …
Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
As modern humans migrated out of Africa, they encountered many new environmental
conditions, including greater temperature extremes, different pathogens and higher …
conditions, including greater temperature extremes, different pathogens and higher …
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations
FF González-Galarza, LYC Takeshita… - Nucleic acids …, 2015 - academic.oup.com
It has been 12 years since the Allele Frequency Net Database (AFND; http://www.
allelefrequencies. net) was first launched, providing the scientific community with an online …
allelefrequencies. net) was first launched, providing the scientific community with an online …