Highlights•Wnt signalling from the plasma membrane to the nucleus involves multiprotein
complexes.•Mechanistic principles underlying the assembly of these complexes are …

Clustering of macromolecules is a fundamental cellular device underlying diverse biological
processes that require high-avidity binding to effectors and substrates. Often, this involves a …

Background Trichoplax adhaerens is the best-known member of the phylum Placozoa, one
of the earliest-diverging metazoan phyla. It is a small disk-shaped animal that glides on …

Extracellular signals are often transduced by dynamic signaling complexes ("
signalosomes") assembled by oligomerizing hub proteins following their recruitment to …

Over the past two decades, mass spectrometry (MS) of protein complexes from their native
state has made inroads into structural biology. To coincide with the 20 th anniversary of …

A key mechanism for guarding against inappropriate activation of signaling molecules is
their weak affinity for effectors, which prevents them from undergoing accidental signal …

The copper-containing superoxide dismutases (SODs) represent a large family of enzymes
that participate in the metabolism of reactive oxygen species by disproportionating …

Heparan sulfate proteoglycan 2 (HSPG2) is an essential, highly conserved gene whose
expression influences many developmental processes including the formation of the heart …

Placozoa is an enigmatic phylum of simple, microscopic, marine metazoans,. Although
intracellular bacteria have been found in all members of this phylum, almost nothing is …

Communication among cells was paramount to the evolutionary increase in cell type
diversity and, ultimately, the origin of large body size. Across the diversity of Metazoa, there …