Association of vitamin D metabolism gene polymorphisms with autoimmunity: evidence in population genetic studies

AI Ruiz-Ballesteros, MR Meza-Meza… - International journal of …, 2020 - mdpi.com
A high prevalence of vitamin D (calcidiol) serum deficiency has been described in several
autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis (AR), and …

[HTML][HTML] A review of the critical role of vitamin D axis on the immune system

G Daryabor, N Gholijani, FR Kahmini - Experimental and Molecular …, 2023 - Elsevier
In recent years, the physiological and molecular functions of vitamin D (Vit-D) have been
deeply investigated. At first, Vit-D was considered a regulator of mineral and skeletal …

Vitamin D receptor (VDR) gene polymorphism and risk of rheumatoid arthritis (RA): systematic review and meta-analysis

Z Bagheri-Hosseinabadi, D Imani, H Yousefi… - Clinical …, 2020 - Springer
Vitamin D is involved in immune system modulation as well as in calcium and bone
homeostasis, hence plays a role in rheumatoid arthritis (RA) etiopathogenesis. A bulk of …

Vitamin D and rheumatoid arthritis: an ongoing mystery

NL Bragazzi, A Watad, SG Neumann… - Current opinion in …, 2017 - journals.lww.com
Despite advancements synthesized by some recent meta-analyses, the relationship
between vitamin D and RA requires further evaluation. Further research is needed to confirm …

Genome engineering for personalized arthritis therapeutics

SS Adkar, JM Brunger, VP Willard, CL Wu… - Trends in molecular …, 2017 - cell.com
Arthritis represents a family of complex joint pathologies responsible for the majority of
musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis …

Transfer learning for genotype–phenotype prediction using deep learning models

M Muneeb, S Feng, A Henschel - BMC bioinformatics, 2022 - Springer
Background For some understudied populations, genotype data is minimal for genotype-
phenotype prediction. However, we can use the data of some other large populations to …

MTHFR gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis based on 16 studies

Z Bagheri-Hosseinabadi, D Imani, H Yousefi… - Clinical …, 2020 - Springer
Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease, in which an
epigenetic implication in the disease etiopathogenesis has been noted. Here in this meta …

[HTML][HTML] Identification of potential genetic causal variants for rheumatoid arthritis by whole-exome sequencing

Y Li, ELH Leung, H Pan, X Yao, Q Huang, M Wu, T Xu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Rheumatoid arthritis (RA) is a highly prevalent chronic autoimmune disease. However,
genetic and environmental factors involved in RA pathogenesis are still remained largely …

MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis

J Zhu, Z Wang, L Tao, L Han, Q Huang, X Fang… - Frontiers in …, 2022 - frontiersin.org
Aims To assess whether MTHFR rs1801131 and rs1801133 SNPs are associated with
concomitant psoriatic arthritis (PsA) and investigate the efficacy and hepatotoxicity of MTX in …

Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A> C polymorphism with Vitiligo susceptibility in Gujarat

SD Jadeja, MS Mansuri, M Singh, H Patel… - Journal of …, 2018 - Elsevier
Background Several studies have reported hyperhomocysteinemia in vitiligo patients,
suggesting the potential role of elevated homocysteine levels in precipitating vitiligo …