Although hybrid crop varieties are among the most popular agricultural innovations, the
rationale for hybrid crop breeding is sometimes misunderstood. Hybrid breeding is slower …

As organisms evolve, the effects of mutations change as a result of epistatic interactions with
other mutations accumulated along the line of descent. This can lead to shifts in adaptability …

Abstract Machine learning has been increasingly used for protein engineering. However,
because the general sequence contexts they capture are not specific to the protein being …

The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …

Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …

How can we treat cancer more effectively? Traditionally, tumours from the same anatomical
site are treated as one tumour entity. This concept has been challenged by recent …

Despite advances in high-throughput sequencing that have revolutionized the discovery of
gene defects in rare Mendelian diseases, there are still gaps in translating individual …

Several types of pediatric cancers reportedly contain high-frequency missense mutations in
histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here …

The main forces directing long-term molecular evolution remain obscure. A sizable fraction
of amino-acid substitutions seem to be fixed by positive selection,,,, but it is unclear to what …

Epistasis between genes is traditionally studied with mutations that eliminate protein activity,
but most natural genetic variation is in cis-regulatory DNA and influences gene expression …