In Leydig cell dysfunction, cells respond weakly to stimulation by pituitary luteinizing
hormone, and, therefore, produce less testosterone, leading to primary hypogonadism. The …

Hypogonadism is common in men with sickle cell disease (SCD) with prevalence rates as
high as 25%. Testicular failure (primary hypogonadism) is established as the principal cause …

Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and
cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the …

Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the
absence of sexual arousal. The current pharmacological treatments for SCD-associated …

Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged,
painful erections occurring without sexual arousal or desire. This urological emergency can …

Reduced serum testosterone affects millions of men across the world and has been linked to
several comorbidities, metabolic dysfunctions, and quality of life changes. The standard …

Background Erectile dysfunction is a condition with a rapidly increasing prevalence globally
with a strong correlation to the increase in obesity and cardiovascular disease rates. Aim …

Sickle cell disease (SCD) is a genetic disorder that has been associated with priapism. The
role of hydroxyurea, a common SCD therapy, in influencing the nitric oxide (NO)-cGMP …

Patients with sickle cell disease (SCD) display priapism. Clinical studies have shown a
strong positive correlation between priapism and high levels of intravascular hemolysis in …

The translocator protein 18 kDa (TSPO) is a crucial external mitochondrial protein involved
in cholesterol translocation, which is essential for steroid production. As a primary marker of …