Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

Quantitative mass spectrometry imaging of biological systems

D Unsihuay, D Mesa Sanchez… - Annual review of physical …, 2021 - annualreviews.org
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Imaging mass spectrometry

LA McDonnell, RMA Heeren - Mass spectrometry reviews, 2007 - Wiley Online Library
Imaging mass spectrometry combines the chemical specificity and parallel detection of mass
spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain …

Molecular imaging by mass spectrometry—looking beyond classical histology

K Schwamborn, RM Caprioli - Nature Reviews Cancer, 2010 - nature.com
Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)
is a new and effective tool for molecular studies of complex biological samples such as …

Multimodal imaging mass spectrometry: next generation molecular map** in biology and medicine

EK Neumann, KV Djambazova… - Journal of the …, 2020 - ACS Publications
Imaging mass spectrometry has become a mature molecular map** technology that is
used for molecular discovery in many medical and biological systems. While powerful by …

Cellular resolution in clinical MALDI mass spectrometry imaging: the latest advancements and current challenges

K Ščupáková, B Balluff, C Tressler… - Clinical Chemistry and …, 2020 - degruyter.com
Mass spectrometry (MS) is the workhorse of metabolomics, proteomics and lipidomics. Mass
spectrometry imaging (MSI), its extension to spatially resolved analysis of tissues, is a …

Tissue protein imaging at 1 μm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS

A Zavalin, J Yang, K Hayden, M Vestal… - Analytical and …, 2015 - Springer
We have achieved protein imaging mass spectrometry capabilities at sub-cellular spatial
resolution and at high acquisition speed by integrating a transmission geometry ion source …

Imaging mass spectrometry: instrumentation, applications, and combination with other visualization techniques

A Bodzon‐Kulakowska, P Suder - Mass spectrometry reviews, 2016 - Wiley Online Library
Imaging Mass Spectrometry (IMS) is strengthening its position as a valuable analytical tool. It
has unique ability to identify structures and to unravel molecular changes that occur in the …

MALDI TOF imaging mass spectrometry in clinical pathology: a valuable tool for cancer diagnostics

J Kriegsmann, M Kriegsmann… - … journal of oncology, 2014 - spandidos-publications.com
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass
spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the …