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Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability
Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …
Redox control of microglial function: molecular mechanisms and functional significance
Neurodegenerative diseases are characterized by chronic microglial over-activation and
oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) …
oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) …
The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin …
Aims: The response of AMP-activated protein kinase (AMPK) to oxidative stress has been
recently reported but the downstream signals of this response are largely unknown …
recently reported but the downstream signals of this response are largely unknown …
Melatonin stimulates the SIRT 1/Nrf2 signaling pathway counteracting lipopolysaccharide (LPS)‐induced oxidative stress to rescue postnatal rat brain
Aims Lipopolysaccharide (LPS) induces oxidative stress and neuroinflammation both in vivo
and in vitro. Here, we provided the first detailed description of the mechanism of melatonin …
and in vitro. Here, we provided the first detailed description of the mechanism of melatonin …
[PDF][PDF] Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors
ML Pall, S Levine - Sheng Li Xue Bao, 2015 - doctaris.com
The transcription factor Nrf2, nuclear factor erythroid-2-related factor 2, activates the
transcription of over 500 genes in the human genome, most of which have cytoprotective …
transcription of over 500 genes in the human genome, most of which have cytoprotective …
A dual AMPK/Nrf2 activator reduces brain inflammation after stroke by enhancing microglia M2 polarization
Y Wang, Y Huang, Y Xu, W Ruan, H Wang… - Antioxidants & redox …, 2018 - liebertpub.com
Aims: Microglia-mediated neuroinflammation plays an important role in focal ischemic
stroke, a disorder with no effective therapeutic agents. Since microglial polarization to the …
stroke, a disorder with no effective therapeutic agents. Since microglial polarization to the …
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression
Reactive metabolites from carcinogens and oxidative stress can drive genetic mutations,
genomic instability, neoplastic transformation, and ultimately carcinogenesis. Numerous …
genomic instability, neoplastic transformation, and ultimately carcinogenesis. Numerous …
[HTML][HTML] Anti-oxidant and anti-inflammatory effects of ellagic and punicic acid in an in vitro model of cardiac fibrosis
Cardiac fibrosis is a pathological process characterized by an excessive deposition of
extracellular matrix (ECM) and an increased production of fibrillar collagen in the cardiac …
extracellular matrix (ECM) and an increased production of fibrillar collagen in the cardiac …
[HTML][HTML] Omega-3 lipid mediators: modulation of the M1/M2 macrophage phenotype and its protective role in chronic liver diseases
The complex interplay between dietary factors, inflammation, and macrophage polarization
is pivotal in the pathogenesis and progression of chronic liver diseases (CLDs). Omega-3 …
is pivotal in the pathogenesis and progression of chronic liver diseases (CLDs). Omega-3 …
Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism
X Ci, J Zhou, H Lv, Q Yu, L Peng, S Hua - Cell death & disease, 2017 - nature.com
Continued oxidative stress can lead to chronic inflammation, which in turn could mediate
most chronic diseases including cancer. Nuclear factor erythroid 2-related factor (Nrf2), a …
most chronic diseases including cancer. Nuclear factor erythroid 2-related factor (Nrf2), a …