The gut microbiome is a complex ecosystem of microorganisms and their genetic entities
colonizing the gastrointestinal tract. When in balanced composition, the gut microbiome is in …

It has recently been recognized that pathology of age-associated degenerative eye diseases
such as adult macular degeneration (AMD), glaucoma and diabetic retinopathy, have strong …

Activated retina-specific T cells that have acquired the ability to break through the blood-
retinal barrier are thought to be causally involved in autoimmune uveitis, a major cause of …

Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …

Lyme disease was originally identified in Lyme, Connecticut, based upon an unusual cluster
of what appeared to be patients with juvenile rheumatoid arthritis. It was subsequently …

Commensal microbes affect all aspects of immune development and homeostasis in health
and disease. Increasing evidence points to the notion that the gut commensals impact not …

IgA is the most abundant immunoglobulin in the human body, and performs a very
specialized role which involves mucosal immunity, development of tolerance and protection …

Abstract Anti-Ro52 (or anti-TRIM21) antibodies are part of the family of anti-Ro/SSA
antibodies, historically markers of Sjögren syndrome and systemic lupus erythematosus …

Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle
(HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are …

Uveitis is the most common ophthalmological finding in the practice of rheumatology and
clinical immunology. The condition is frequently idiopathic and defined by the inflammatory …