The Actinomycetales order is one of great genetic and functional diversity, including diversity
in the production of secondary metabolites which have uses in medical, environmental …

Rare actinomycetes are prolific in the marine environment; however, knowledge about their
diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a …

Actinobacteria are Gram-positive bacteria with high G+ C DNA content that constitute one of
the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and …

Antimicrobial resistance (AR) is recognized as one of the greatest threats to public health
and in global concern. Consequently, the increased morbidity and mortality, which are …

Marine actinobacteria are one of the most efficient groups of secondary metabolite
producers and are very important from an industrial point of view. Many representatives of …

Actinomycetes are virtually unlimited sources of novel compounds with many therapeutic
applications and hold a prominent position due to their diversity and proven ability to …

Actinobacteria, which share the characteristics of both bacteria and fungi, are widely dis-
tributed in both terrestrial and aquatic ecosystems, mainly in soil, where they play an es …

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …

Access to genome sequence data has challenged traditional natural product discovery
paradigms by revealing that the products of most bacterial biosynthetic pathways have yet to …

During the past 15 years, most large pharmaceutical companies have decreased the
screening of natural products for drug discovery in favor of synthetic compound libraries …