The aging cardiovascular system: understanding it at the cellular and clinical levels
Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers,
and health systems. Structural and functional alterations of vessels accumulate throughout …
and health systems. Structural and functional alterations of vessels accumulate throughout …
Heart regeneration by endogenous stem cells and cardiomyocyte proliferation: controversy, fallacy, and progress
Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …
A Phase II study of autologous mesenchymal stromal cells and c‐kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN …
Aims CONCERT‐HF is an NHLBI‐sponsored, double‐blind, placebo‐controlled, Phase II
trial designed to determine whether treatment with autologous bone marrow‐derived …
trial designed to determine whether treatment with autologous bone marrow‐derived …
An update on the progress of isolation, culture, storage, and clinical application of human bone marrow mesenchymal stem/stromal cells
DT Chu, TNT Phuong, NLB Tien, DK Tran… - International journal of …, 2020 - mdpi.com
Bone marrow mesenchymal stem/stromal cells (BMSCs), which are known as multipotent
cells, are widely used in the treatment of various diseases via their self-renewable …
cells, are widely used in the treatment of various diseases via their self-renewable …
Clinical studies of cell therapy in cardiovascular medicine: recent developments and future directions
Given the rising prevalence of cardiovascular disease worldwide and the limited therapeutic
options for severe heart failure, novel technologies that harness the regenerative capacity of …
options for severe heart failure, novel technologies that harness the regenerative capacity of …
Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI
X Ai, B Yan, N Witman, Y Gong, L Yang, Y Tan… - Molecular Therapy, 2023 - cell.com
Cell-based therapies offer an exciting and novel treatment for heart repair following
myocardial infarction (MI). However, these therapies often suffer from poor cell viability and …
myocardial infarction (MI). However, these therapies often suffer from poor cell viability and …
Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
Acute myocardial infarction and chronic heart failure rank among the major causes of
morbidity and mortality worldwide. Except for heart transplantation, current therapy options …
morbidity and mortality worldwide. Except for heart transplantation, current therapy options …
Global position paper on cardiovascular regenerative medicine
Based on the increasingly understood regenerative capacity of the human heart and
vascular system, 1 cardiovascular regenerative medicine (CRM) encompasses all potential …
vascular system, 1 cardiovascular regenerative medicine (CRM) encompasses all potential …
Therapies to prevent post-infarction remodelling: From repair to regeneration
P Contessotto, A Pandit - Biomaterials, 2021 - Elsevier
Myocardial infarction is the first cause of worldwide mortality, with an increasing incidence
also reported in develo** countries. Over the past decades, preclinical research and …
also reported in develo** countries. Over the past decades, preclinical research and …
Mending a broken heart: current strategies and limitations of cell-based therapy
The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity
and plasticity, has sparked a considerable interest for potential application in regenerative …
and plasticity, has sparked a considerable interest for potential application in regenerative …