In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a
supportive fibroblast-rich extracellular matrix designed to optimize the electromechanical …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

How early (EADs) and delayed afterdepolarizations (DADs) overcome electrotonic source-
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …

In this paper, we study a mathematical model of cardiac tissue based on explicit
representation of individual cells. In this EMI model, the extracellular (E) space, the cell …

Atrial fibrillation (AF) is the most common form of cardiac arrhythmia, often evolving from
paroxysmal episodes to persistent stages over an extended timeframe. While various factors …

Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that
drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small …

QT prolongation, due to lengthening of the action potential duration in the ventricles, is a
major risk factor of lethal ventricular arrhythmias. A widely known consequence of QT …

Early afterdepolarizations (EADs) are linked to both triggered arrhythmias and reentrant
arrhythmias by causing premature ventricular complexes (PVCs), focal excitations, or …

Background: In cardiac gene therapy to improve contractile function, achieving gene
expression in the majority of cardiac myocytes is essential. In preventing cardiac …

Cardiac stimulation via sympathetic neurons can potentially trigger arrhythmias. We present
approaches to study neuron-cardiomyocyte interactions involving optogenetic selective …