[HTML][HTML] Uric acid and chronic kidney disease: still more to do
Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …
disease (CKD), respectively. Despite the common association, the role of uric acid in the …
Pathological mechanisms of kidney disease in ageing
T Yamamoto, Y Isaka - Nature Reviews Nephrology, 2024 - nature.com
The kidney is a metabolically active organ that requires energy to drive processes such as
tubular reabsorption and secretion, and shows a decline in function with advancing age …
tubular reabsorption and secretion, and shows a decline in function with advancing age …
Klotho and calciprotein particles as therapeutic targets against accelerated ageing
M Kuro-o - Clinical Science, 2021 - portlandpress.com
The klotho gene, named after a Greek goddess who spins the thread of life, was identified as
a putative 'ageing-suppressor'gene. Klotho-deficient mice exhibit complex ageing-like …
a putative 'ageing-suppressor'gene. Klotho-deficient mice exhibit complex ageing-like …
Phenotypic and functional alterations of monocyte subsets with aging
Y Cao, Y Fan, F Li, Y Hao, Y Kong, C Chen, X Hao… - Immunity & …, 2022 - Springer
Background It has been widely accepted that monocytes are one of the central mediators
contributing to inflammaging. However, it remains unclear whether aged monocytes, similar …
contributing to inflammaging. However, it remains unclear whether aged monocytes, similar …
Emerging cross-talks between chronic kidney disease–mineral and bone disorder (CKD–MBD) and malnutrition–inflammation complex syndrome (MICS) in patients …
S Yamada, K Tsuruya, T Kitazono, T Nakano - Clinical and Experimental …, 2022 - Springer
Chronic kidney disease–mineral and bone disorder (CKD–MBD) is a systemic disorder that
affects multiple organs and systems and increases the risk of morbidity and mortality in …
affects multiple organs and systems and increases the risk of morbidity and mortality in …
The basics of phosphate metabolism
CA Wagner - Nephrology Dialysis Transplantation, 2024 - academic.oup.com
Phosphorus is an essential mineral that is, in the form of inorganic phosphate (Pi), required
for building cell membranes, DNA and RNA molecules, energy metabolism, signal …
for building cell membranes, DNA and RNA molecules, energy metabolism, signal …
The emerging role of magnesium in CKD
Y Sakaguchi - Clinical and experimental nephrology, 2022 - Springer
Increasing evidence has suggested a clinical relevance of magnesium in the context of
vascular calcification and mortality among patients with CKD. Hypomagnesemia is not rare …
vascular calcification and mortality among patients with CKD. Hypomagnesemia is not rare …
Focusing on phosphorus loads: from healthy people to chronic kidney disease
M Wang, J Zhang, K Kalantar-Zadeh, J Chen - Nutrients, 2023 - mdpi.com
Phosphorus is an essential micromineral with a key role in cellular metabolism and tissue
structure. Serum phosphorus is maintained in a homeostatic range by the intestines, bones …
structure. Serum phosphorus is maintained in a homeostatic range by the intestines, bones …
Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling
Elevations in plasma phosphate concentrations (hyperphosphatemia) occur in chronic
kidney disease (CKD), in certain genetic disorders, and following the intake of a phosphate …
kidney disease (CKD), in certain genetic disorders, and following the intake of a phosphate …
Phosphate intake, hyperphosphatemia, and kidney function
I Rubio-Aliaga, R Krapf - Pflügers Archiv-European Journal of Physiology, 2022 - Springer
Phosphate is essential in living organisms and its blood levels are regulated by a complex
network involving the kidneys, intestine, parathyroid glands, and the skeleton. The crosstalk …
network involving the kidneys, intestine, parathyroid glands, and the skeleton. The crosstalk …