Miscarriage is generally defined as the loss of a pregnancy before viability. An estimated 23
million miscarriages occur every year worldwide, translating to 44 pregnancy losses each …

Recurrent pregnancy loss is a distressing pregnancy disorder experienced by~ 2.5% of
women trying to conceive. Recurrent pregnancy loss is defined as the failure of two or more …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Decidual remodelling of midluteal endometrium leads to a short implantation window after
which the uterine mucosa either breaks down or is transformed into a robust matrix that …

Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the
endometrium before the placental trophoblast invades beyond the uterine mucosa into the …

Recurrent pregnancy loss (RPL) represents an unresolved problem for contemporary
gynecology and obstetrics. In fact, it is not only a relevant complication of pregnancy, but is …

In cycling human endometrium, menstruation is followed by rapid estrogen-dependent
growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the …

Progesterone is essential for the maintenance of pregnancy. Several small trials have
suggested that progesterone supplementation may reduce the risk of miscarriage in women …

During the implantation window, the endometrium becomes poised to transition to a
pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC) …