Simple Summary Monoclonal antibodies (mAbs) have the ability to specifically target tumor-
cell antigens. This unique property has led to their use in the delivery of radioisotopes to …

In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (CSC; or
tumor‐initiating cells) is characterized by self‐renewal, unlimited proliferative potential …

Reprogramming of NK cells with a chimeric antigen receptor (CAR) proved an effective
strategy to increase NK cell reactivity and recognition specificity toward tumor cells. To …

Adoptive immunotherapy with T cells expressing a tumor-associated chimeric antigen
receptor (CAR) provides a promising approach for tumor therapy. We designed a clinical …

Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Over the past few decades, understanding how tumor cells evade the immune system and
their communication with their tumor microenvironment, has been the subject of intense …

Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for
maintaining normal cell morphology, interacting with the extracellular and intracellular …

Abstract Syndecan-1 (SDC1, CD138) is a key cell surface adhesion molecule essential for
maintaining cell morphology and interaction with the surrounding microenvironment …

The introduction of proteasome inhibitors (PI) and immunomodulatory drugs (IMiD) has
markedly increased the survival of multiple myeloma (MM) patients. Also, the unconjugated …

Proteoglycans are major constituents of extracellular matrices, as well as cell surfaces and
basement membranes. They play key roles in supporting the dynamic extracellular matrix by …