Ordered protein aggregation in the brain is a hallmark of Alzheimer's disease and scrapie.
The disease-specific amyloid fibrils comprise primarily a single protein, amyloid β, in …

▪ Abstract Prion diseases are transmissible neurodegenerative conditions that include
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …

Here, we use single-molecule techniques to study the aggregation of α-synuclein, the
protein whose misfolding and deposition is associated with Parkinson's disease. We identify …

Prions are the infectious agents responsible for transmissible spongiform encephalopathies.
The principal component of prions is the glycoprotein PrPSc, which is a conformationally …

Bacterial cells sense their population density through a sophisticated cell–cell
communication system and trigger expression of particular genes when the density reaches …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Transthyretin (TTR) amyloid fibril formation is observed during partial acid denaturation and
while refolding acid-denatured TTR, implying that amyloid fibril formation results from the …

Transgenic (Tg) mice expressing human (Hu) and chimerit prion protein (PrP) genes were
inoculated with brain extracts from humans with inherited or sporadic prion disease to …

The conformational change of a host protein, PrPC, into a disease-associated isoform,
PrPSc, appears to play a critical role in the pathogenesis of prion diseases such as …

The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic,
structures poses a universal problem for all types of cell. This tendency is greatly …