Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …

Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …

Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory
characteristics are incompletely understood. Objectives: To define the cytokine profile of …

Chronic obstructive pulmonary disease (COPD), a major cause of death and morbidity
worldwide, is characterized by expiratory airflow limitation that is not fully reversible …

Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory …

Neutrophils are the predominant immune cells in human blood possessing heterogeneity,
plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed …

Studies have endeavored to reconcile whether dysfunction of neutrophils in people with
cystic fibrosis (CF) is a result of the genetic defect or is secondary due to infection and …

Acute phase proteins (APPs) are a group of circulating plasma proteins which undergo
changes quantitatively or qualitatively at the time of inflammation. Many of these APPs are …

Chronic obstructive pulmonary disease (COPD), a chronic airway disorder, which is mostly
brought on by cigarette smoke extract (CSE), is a leading cause of death which has a high …

Bullous pemphigoid (BP) is by far the most common autoimmune blistering dermatosis that
mainly occurs in the elderly. The BP180 is a transmembrane glycoprotein, which is highly …