Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …

Background Mutations of the gene TMEM106B are risk factors for diverse
neurodegenerative diseases. Previous understanding of the underlying mechanism focused …

Genetic variation at the transmembrane protein 106B gene (TMEM106B) has been linked to
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …

Since the initial identification of TMEM106B as a risk factor for frontotemporal lobar
degeneration (FTLD), multiple genetic studies have found TMEM106B variants to modulate …

A common feature of adult-onset neurodegenerative diseases is the presence of
characteristic pathological accumulations of specific proteins. These pathological protein …

TMEM106B, a gene encoding a lysosome membrane protein, is tightly associated with brain
aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases …

Abstract TMEM106B, a type II lysosomal transmembrane protein, has recently been
associated with brain aging, hypomyelinating leukodystrophy, frontotemporal lobar …

Suspension TRAP** filter (sTRAP) is an attractive sample preparation method for
proteomics studies. The sTRAP protocol uses 5% SDS that maximizes protein solubilization …

Abstract Transmembrane protein 106B (TMEM106B), previously identified as a risk factor in
frontotemporal lobar degeneration, has recently been detected to form fibrillar aggregates in …

Genome-wide association studies identified a role for TMEM106B in various
neurodegenerative diseases. Based on long-read whole-genome sequencing data of 256 …