[HTML][HTML] FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition
H Corvol, N Rousselet, KE Thompson, L Berdah… - Journal of Cystic …, 2018 - Elsevier
Background Cystic fibrosis (CF) lung disease severity is highly variable and dependent on
several factors including genetic modifiers. Family with sequence similarity 13 member A …
several factors including genetic modifiers. Family with sequence similarity 13 member A …
Bacterial lipopolysaccharide inhibits free thiamin uptake along the intestinal tract via interference with membrane expression of thiamin transporters 1 and 2
This study examined the effect of exposure of small and large intestinal epithelial cells to the
bacterial lipopolysaccharide (LPS) on uptake of free form of vitamin B1, ie, thiamin. The …
bacterial lipopolysaccharide (LPS) on uptake of free form of vitamin B1, ie, thiamin. The …
Silencing of CDC42 inhibits contraction and growth-related functions in prostate stromal cells, which is mimicked by ML141
R Wang, R Huang, Y Liu, A Tamalunas, CG Stief… - Life Sciences, 2023 - Elsevier
Background Prostate smooth muscle contraction and stromal growth may contribute to lower
urinary tract symptoms suggestive of benign prostatic hyperplasia, but are incompletely …
urinary tract symptoms suggestive of benign prostatic hyperplasia, but are incompletely …
[HTML][HTML] CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway: CTNNAL1 increases …
D Wu, J Zhu, F Yang, R Li, L Liu, D Liu… - Acta Biochimica et …, 2023 - ncbi.nlm.nih.gov
The downregulation of adhesion molecule catenin alpha-like 1 (CTNNAL1) in airway
epithelial cells of asthma patients and house dust mite (HDM)-induced asthma animal …
epithelial cells of asthma patients and house dust mite (HDM)-induced asthma animal …
Unravelling druggable signalling networks that control F508del-CFTR proteostasis
Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator
(CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is …
(CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is …
Interaction of the small GTPase Cdc42 with arginine kinase restricts white spot syndrome virus in shrimp
JD Xu, HS Jiang, TD Wei, KY Zhang, XW Wang… - Journal of …, 2017 - Am Soc Microbiol
Many types of small GTPases are widely expressed in eukaryotes and have different
functions. As a crucial member of the Rho GTPase family, Cdc42 serves a number of …
functions. As a crucial member of the Rho GTPase family, Cdc42 serves a number of …
Extracting insights from temporal data by integrating dynamic modeling and machine learning
R Ballweg, KA Engevik, MH Montrose, E Aihara… - Frontiers in …, 2020 - frontiersin.org
Biological processes are dynamic. As a result, temporal analyses are necessary to fully
understand the complex interactions that occurs within these systems. One example of a …
understand the complex interactions that occurs within these systems. One example of a …
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency
P Kashani, A Marwaha, S Feanny, VHD Kim… - Immunologic …, 2021 - Springer
Single allele mutations in the Cell Division Control protein 42 homolog (CDC42) gene were
recently shown to cause Takenouchi-Kosaki syndrome with diverse manifestations. These …
recently shown to cause Takenouchi-Kosaki syndrome with diverse manifestations. These …
Cyclic stretch-induced the cytoskeleton rearrangement and gene expression of cytoskeletal regulators in human periodontal ligament cells
Y Wu, J Zhuang, D Zhao, F Zhang, J Ma… - Acta Odontologica …, 2017 - Taylor & Francis
Objective: This study aimed to explore the mechanism of the stretch-induced cell
realignment and cytoskeletal rearrangement by identifying several mechanoresponsive …
realignment and cytoskeletal rearrangement by identifying several mechanoresponsive …
[HTML][HTML] The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans
Abnormal regulation of cell migration and altered rearrangement of the cytoskeleton are
fundamental properties of metastatic cells. The first identified metastasis suppressor NM23 …
fundamental properties of metastatic cells. The first identified metastasis suppressor NM23 …