Regioselective difunctionalization and annulation of ynamide
The use of ynamides in organic synthesis has gained significant attention due to their ability
to provide access to complex molecular structures through transformations such as 1, 2 …
to provide access to complex molecular structures through transformations such as 1, 2 …
Enamine Synthesis via Regiocontrolled 6‐endo‐dig and 5‐exo‐dig Tethered Carboamination of Propargylic Alcohols
H Solé‐Àvila, M Puriņš, L Eichenberger… - Angewandte …, 2024 - Wiley Online Library
Enamines are versatile building blocks for the synthesis of biologically active compounds.
Nevertheless, only a limited number of strategies have been reported for preparing …
Nevertheless, only a limited number of strategies have been reported for preparing …
Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero) arenes and iodine (iii) electrophile
The three-component Friedel–Crafts type functionalization of an electron-rich arene using
an electrophile-activated alkyne can offer a strategy for rapidly constructing densely …
an electrophile-activated alkyne can offer a strategy for rapidly constructing densely …
Copper-Catalyzed Regio-and Stereoselective Hydroarylation of Ynamide
Presented herein is a copper-catalyzed trans-hydroarylation of ynamides. The reaction
showcases the assembly of boronic acids across the carbon–carbon triple bond of …
showcases the assembly of boronic acids across the carbon–carbon triple bond of …
Regioselective syn-1, 2-hydroarylation of internal alkynes
The regioselective hydro-functionalization reaction is a powerful method to convert readily
available alkynes into structurally diverse olefins. Such an efficient syn-1, 2-hydroarylation of …
available alkynes into structurally diverse olefins. Such an efficient syn-1, 2-hydroarylation of …
Synthetic Strategy for Unsymmetrical α-Fluoro-α′-aryl Ketones
α-Fluoro-α′-aryl ketones are crucial in pharmaceuticals and agrochemicals. However,
synthesizing unsymmetrical α-fluoro-α′-aryl ketones poses regioselective challenges. This …
synthesizing unsymmetrical α-fluoro-α′-aryl ketones poses regioselective challenges. This …
Palladium-catalyzed syn-alkynylarylation of internal alkynes: rapid access to all-carbon tetrasubstituted alkenes
R Ma, X Qiu, H Jiang, W Wu - Chemical Communications, 2024 - pubs.rsc.org
Herein, a straightforward method for rapid access to all-carbon tertrasubstituted alkenes
bearing alkyl, aryl and alkynyl groups is established via palladium-catalyzed three …
bearing alkyl, aryl and alkynyl groups is established via palladium-catalyzed three …
Photoredox Radical Cascade Cyclization of 2‐Alkynylarylnitriles in Visible Light: Direct Access to 3‐Amino‐1‐indenones
A photoinduced direct synthesis of 3‐amino‐1‐indenones via radical cascade cyclization
strategy is demonstrated. The methodology involves a domino reaction between 2 …
strategy is demonstrated. The methodology involves a domino reaction between 2 …
Two-component symmetrical diarylation of ynamides
The present study describes a method for the dicarbofunctionalization of ynamide via a
palladium-catalyzed two-component diarylation with aryl boronic acids. The reaction …
palladium-catalyzed two-component diarylation with aryl boronic acids. The reaction …
Base‐Promoted Structural Rearrangement of Ynamide and Simultaneous N‐Desulfonylation
M Reddy Mutra, TL Chandana… - … Synthesis & Catalysis, 2024 - Wiley Online Library
Herein, we describe a base‐promoted regioselective and chemoselective cascade
cyclization, ynamide N− Csp bond cleavage, selective intramolecular 1, 3‐migration, and …
cyclization, ynamide N− Csp bond cleavage, selective intramolecular 1, 3‐migration, and …