The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Chemokines are a group of about 50 chemotactic cytokines crucial for the migration of
immune system cells and tumor cells, as well as for metastasis. One of the 20 chemokine …

Ageing is correlated with elevated bladder cancer incidence, morbidity and mortality.
Advanced age is also associated with elevated markers of chronic inflammation and …

Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel
through the vasculature and invade new tissues can remain in a non-proliferative dormant …

Mounting experimental evidence from in vitro and in vivo animal studies points to an
essential role of the CXCL8-CXCR1/2 axis in neutrophils in the pathophysiology of …

Metastasis and chemoresistance are two major causes of breast cancer death. We show
here that the chemokine receptor CXCR2 was overexpressed in breast cancer cell lines and …

Simple Summary While the development of immunotherapy has greatly advanced cancer
treatment, many patients do not benefit from immunotherapy. Numerous strategies have …

Chemokines, a subfamily of the cell cytokines, are low molecular weight proteins known to
induce chemotaxis in leukocytes in response to inflammatory and pathogenic signals. A …

Simple Summary Tumor cell–neutrophil interactions play an important role in tumor
progression, metastasis, and overall survival. The purpose of this study was to examine the …

Recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment
(TME) contributes to cancer immune evasion. MDSCs express the chemokine receptor …