Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

Management of hepatocellular carcinoma in Japan: JSH consensus statements and recommendations 2021 update

M Kudo, Y Kawamura, K Hasegawa, R Tateishi… - Liver cancer, 2021 - karger.com
Abstract The Clinical Practice Manual for Hepatocellular Carcinoma was published based
on evidence confirmed by the Evidence-based Clinical Practice Guidelines for …

Hepatic arterial infusion of oxaliplatin, fluorouracil, and leucovorin versus transarterial chemoembolization for large hepatocellular carcinoma: a randomized phase III …

QJ Li, MK He, HW Chen, WQ Fang, YM Zhou… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE In a previous phase II trial, hepatic arterial infusion chemotherapy (HAIC) with
infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX) yielded higher treatment …

[HTML][HTML] Achievement of complete response and drug-free status by atezolizumab plus bevacizumab combined with or without curative conversion in patients with …

M Kudo, T Aoki, K Ueshima, K Tsuchiya, M Morita… - Liver cancer, 2023 - karger.com
Introduction: Atezolizumab plus bevacizumab therapy is extremely effective in the treatment
of intermediate-stage hepatocellular carcinoma (HCC), with a response rate of 44%, as …

Sequential transarterial chemoembolisation and stereotactic body radiotherapy followed by immunotherapy as conversion therapy for patients with locally advanced …

CL Chiang, KWH Chiu, KSK Chan, FAS Lee… - The Lancet …, 2023 - thelancet.com
Background The synergy between locoregional therapies and immune checkpoint inhibitors
has not been investigated as conversion therapy for unresectable hepatocellular carcinoma …

Clinical practice guidelines and real-life practice in hepatocellular carcinoma: A Chinese perspective

D **e, J Shi, J Zhou, J Fan… - Clinical and molecular …, 2022 - pmc.ncbi.nlm.nih.gov
Liver cancer is the fourth most prevalent and the second most lethal cancer in China.
Hepatitis B virus (HBV) infection represents a major risk factor for hepatocellular carcinoma …

Breakthroughs in hepatocellular carcinoma therapies

AG Singal, M Kudo, J Bruix - Clinical Gastroenterology and Hepatology, 2023 - Elsevier
Several breakthroughs in hepatocellular carcinoma (HCC) therapy across tumor stages
provide hope to improve its dismal prognosis. Although surgical and local ablative therapies …

[HTML][HTML] A phase 2, prospective, multicenter, single-arm trial of transarterial chemoembolization therapy in combination strategy with lenvatinib in patients with …

M Kudo, K Ueshima, I Saeki, T Ishikawa, Y Inaba… - Liver cancer, 2024 - karger.com
Introduction: Transarterial chemoembolization (TACE) is the standard treatment for
unresectable intermediate-stage hepatocellular carcinoma (HCC), but recurrence after …

Final results of TACTICS: a randomized, prospective trial comparing transarterial chemoembolization plus sorafenib to transarterial chemoembolization alone in …

M Kudo, K Ueshima, M Ikeda, T Torimura, N Tanabe… - Liver cancer, 2022 - karger.com
Introduction: Several clinical trials comparing the efficacy and safety of transarterial
chemoembolization (TACE) plus molecular-targeted agents versus TACE alone revealed no …

[HTML][HTML] Atezolizumab plus bevacizumab followed by curative conversion (ABC conversion) in patients with unresectable, TACE-unsuitable intermediate-stage …

M Kudo - Liver cancer, 2022 - karger.com
Atezolizumab plus bevacizumab (Atezo/Bev) followed by curative conversion (ABC
conversion) therapy is very effective in the treatment of unresectable, transarterial …