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Shared and distinct mechanisms of fibrosis
JHW Distler, AH Györfi, M Ramanujam… - Nature Reviews …, 2019 - nature.com
Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β-catenin signaling activation
M Katoh - International journal of molecular medicine, 2018 - spandidos-publications.com
β-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules
(E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and α-catenins), transmembrane …
(E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and α-catenins), transmembrane …
Targeting TGF-β signaling for the treatment of fibrosis
Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …
Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis
T Trinh-Minh, CW Chen, CT Manh, YN Li, H Zhu… - The Journal of Clinical …, 2024 - jci.org
Transforming growth factor β (TGF-β) signaling is a core pathway of fibrosis, but the
molecular regulation of the activation of latent TGF-β remains incompletely understood …
molecular regulation of the activation of latent TGF-β remains incompletely understood …
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of
fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several …
fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several …
Understanding the impact of fibroblast heterogeneity on skin fibrosis
Tissue fibrosis is the deposition of excessive extracellular matrix and can occur as part of the
body's natural wound healing process upon injury, or as a consequence of diseases such as …
body's natural wound healing process upon injury, or as a consequence of diseases such as …
The WNT signaling pathways in wound healing and fibrosis
The WNT signaling pathways are major regulators of organ development. Ample research
over the past few decades revealed that these pathways are critically involved in adult tissue …
over the past few decades revealed that these pathways are critically involved in adult tissue …
Dipeptidylpeptidase 4 as a marker of activated fibroblasts and a potential target for the treatment of fibrosis in systemic sclerosis
Objective Expression of dipeptidylpeptidase 4 (DPP‐4) identifies a dermal fibroblast lineage
involved in scarring during wound healing. The role of DDP‐4 in tissue fibrosis is, however …
involved in scarring during wound healing. The role of DDP‐4 in tissue fibrosis is, however …
The role of Wnt signaling in skin fibrosis
Skin fibrosis is the excessive deposition of extracellular matrix in the dermis. Cutaneous
fibrosis can occur following tissue injury, including burns, trauma, and surgery, resulting in …
fibrosis can occur following tissue injury, including burns, trauma, and surgery, resulting in …
is Wnt signaling an attractive target for the treatment of osteoarthritis?
Osteoarthritis is the most common chronic joint disease affecting millions of people
worldwide and a leading cause of pain and disability. Increasing incidence of obesity and …
worldwide and a leading cause of pain and disability. Increasing incidence of obesity and …