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Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance
The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic
innervation of the human cerebral cortex. They are involved in the cognitive processes of …
innervation of the human cerebral cortex. They are involved in the cognitive processes of …
[HTML][HTML] Improving anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: are irreversible inhibitors the future?
DE Moss - International journal of molecular sciences, 2020 - mdpi.com
Decades of research have produced no effective method to prevent, delay the onset, or slow
the progression of Alzheimer's disease (AD). In contrast to these failures …
the progression of Alzheimer's disease (AD). In contrast to these failures …
[HTML][HTML] Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
Background Cognitive abilities, particularly memory, normally decline with age. However,
some individuals, often designated as superagers, can reach late life with the memory …
some individuals, often designated as superagers, can reach late life with the memory …
[HTML][HTML] Tebuconazole alters morphological, behavioral and neurochemical parameters in larvae and adult zebrafish (Danio rerio)
In this study, we evaluated the effects of tebuconazole on morphology and exploratory
larvae behavior and adult locomotion. Furthermore, we analyzed the effects of this fungicide …
larvae behavior and adult locomotion. Furthermore, we analyzed the effects of this fungicide …
Understanding brain resilience in superagers: a systematic review
Purpose Superagers are older adults presenting excellent memory performance that may
reflect resilience to the conventional pathways of aging. Our contribution aims to shape the …
reflect resilience to the conventional pathways of aging. Our contribution aims to shape the …
[HTML][HTML] Rosiridin attenuates scopolamine-induced cognitive impairments in rats via inhibition of oxidative and nitrative stress leaded caspase-3/9 and TNF-α signaling …
Aim: A monoterpene and bioactive component of the plant Rhodiola rosea (R. rosea),
rosiridin has beneficial effects on the human central nervous system and enhances brain …
rosiridin has beneficial effects on the human central nervous system and enhances brain …
Cognitively high-performing oldest old individuals are physically active and have strong motor skills–A study of the Danish 1905 and 1915 birth cohorts
Preserving cognitive function with age or super-aging greatly contributes to successful
aging. Super-aging nonagenarians born in Denmark in either year 1905 or 1915 were …
aging. Super-aging nonagenarians born in Denmark in either year 1905 or 1915 were …
Integrity of neuronal size in the entorhinal cortex is a biological substrate of exceptional cognitive aging
Average aging is associated with a gradual decline of memory capacity. SuperAgers are
humans≥ 80 years of age who show exceptional episodic memory at least as good as …
humans≥ 80 years of age who show exceptional episodic memory at least as good as …
Walnut oil prevents scopolamine-induced memory dysfunction in a mouse model
For thousands of years, it has been widely believed that walnut is a kind of nut that has
benefits for the human body. Walnut oil, accounting for about 70% of walnut, mainly consists …
benefits for the human body. Walnut oil, accounting for about 70% of walnut, mainly consists …
Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex
Cholinergic synapses in prefrontal cortex are vital for attention, but this modulatory system
undergoes substantial pre-and post-synaptic alterations during adulthood. To examine the …
undergoes substantial pre-and post-synaptic alterations during adulthood. To examine the …